Selected Publications


O'Brien, L.E., Soliman, S., Li, X., & Bilder D. (2011)
Altered modes of stem cell division drive adaptive intestinal growth.
Cell 147:603-14.

This work showed that stem cells not only renew and repair mature tissues, but also resize adult organs in response to physiologic triggers. In adult Drosophila, the intestine exploits its renewal program to adapt to increased dietary load. Stimulated by ingested food and an insulin signal from the niche, intestinal stem cells expand the gut through a reversible growth program in which divisions are accelerated and skewed toward symmetric fates.

Comment in:
Cell (2011) 147:487-9
Nat. Rev. Mol. Cell. Biol. (2011) 12:768
Faculty of 1000
O'Brien, L.E., Tang, K., Kats, E.S., Schutz-Geschwender, A., Lipschutz, J.H., & Mostov, K.E. (2004)
ERK and MMPs sequentially regulate distinct stages of epithelial tubule development.
Dev. Cell 7:21-32.

This study provided insight into temporal regulation of the complex morphogenetic events that create multicellular tissues. A single morphogen, Hepatocyte Growth Factor, directs epithelial tubule development by inducing complementary effectors, ERK and MMPs, that control successive steps of tubule formation.

Comment in:
Dev. Cell (2004) 7:3-5
O'Brien, L.E., Zegers, M.M.P., & Mostov, K.E. (2002)
Opinion: Building epithelial architecture: Insights from three-dimensional culture models.
Nat. Rev. Mol. Cell. Biol. 3:531-537.

This review argues that diverse models of epithelial organogenesis can be viewed as a simple combination of two morphogenetic processes: a 'three-surfaces pursuit' together with varying degrees of epithelial-mesenchymal transition.
O'Brien, L.E., Jou, T.S., Hansen, S.H., Pollack, A.L., Zhang, Q., Yurchenco, P.D. & Mostov, K.E. (2001)
Rac1 orients epithelial apical polarity through effects on basolateral laminin assembly.
Nature Cell Biol. 3:831-838.

This work showed that orientation of epithelial polarity relies on cross talk between intracellular signals and the extracellular matrix. During development of kidney organoids, epithelial cells create their own polarity cue by Rac1-mediated assembly of laminin into the basement membrane.

Featured in:
Alberts, B. et al. (2007) Molecular Biology of the Cell, 5th ed., p. 1155